他突然有种难以言喻的孤独感。

He felt a sudden inexpressible loneliness.

他或许没有酒精的味道，但散发出孤独感。

He may not smell of alcohol but he reeks of loneliness.

埃米有越来越强的茫然与孤独感。

Amy had the growing sense that she was adrift and isolated.

当我2006年确诊患有乳腺癌时，我承认在最初的刹那，我有强烈的孤独感。

When I was first diagnosed with cancer back in 2006, I have to admit that it was initially a very lonely experience.

我并没有体会到母亲去世时他的扼腕之情，也没有理解他作为”空巢老人“强烈的孤独感，更没有意识到他许多朋友已经驾鹤西去。

I had not felt his remorse over Mom's death, understood his intense loneliness as an "empty nester, " or realized most of his pals had long since light-beamed off the planet.