大鼠大脑及小脑髓鞘轻度变性，但未见典型脱髓鞘改变。

Mild myelinic degeneration was present in both cerebrum and cerebellum, and no typical demyelination was seen.

方法：分析5例假瘤型炎性脱髓鞘病的临床、影像及病理特点。

Methods: The clinical situation, magnetic resonance imaging (MRI), and pathology of 5 cases of tumor-like inflammatory demyelinating diseases were reported and analyzed.

脱髓鞘病灶分布以双侧侧脑室旁额顶枕叶白质为主，呈圆形或椭圆形，边界清晰。

Demyelinating lesions showed round or oval shape were mainly in bilateral periventricular white matter, and frontal, parietal, occipital white matter.

结论环己酮草酰二腙可诱导大鼠脑白质脱髓鞘、空泡样变，呈时间剂量相关性，随着时间延长和累积剂量增加，细胞凋亡及空泡形成增多；

It was related to the dosage and time. Along with the time extension and the cuprizone dosage increasement, the cell apoptosis increased and the demyelination aggravated.