信息产业在国民经济中的比重不可小视。

Information industry is important role in national economy.

关节痛，尤其是膝盖、脚踝、手肘和手腕部位的疼痛，是不可小视的。

Joint pain, particularly in the joints of the knee, ankle, elbow and wrist, should never be ignored.

而管理8,000英里以外的一大批员工所需要的那些不可小视的费用和个人牺牲使CEO身心俱疲。

And, the not so hidden expense and personal sacrifice needed to manage a large staff 8, 000 miles away have worn down the CEO.