她感到自己孤立无助，非常脆弱。

She was left feeling exposed and vulnerable.

你们已经被无情的操纵，相信自己是孤立无助的。

You have been manipulated without mercy into believing that you are helpless.

他跑掉了，把我一个人丢在黑漆漆的树林里，孤立无助。

He ran away and left me helpless in the dark woods.

现在，比起他出生时我第一次看到的那个孤立无助的小不点，他动作大多了。

Right now, he is much more active than that day when I went to see his helpless little soul right after he was born.